Postdrome Duration:

• Typically lasts 18-25 hours on average.

• 81% of individuals experience at least one non-headache symptom during this period.

Postdrome Symptoms:

• Grouped into Neuropsychiatric, Sensory, Gastrointestinal, and General categories.

• Common symptoms: fatigue, difficulty concentrating, neck stiffness.

Key Structures in Headaches:

• Involves blood vessels, duramater (brain membrane), trigeminovascular system, trigeminal nucleus, and pain-regulating brain systems.

• Dysfunction in brainstem's neuromodulatory structures is a core part of migraine causes.

Locus Coeruleus:

• Important for regulating brain function.

• Activation during migraine attacks, especially in the postdrome, may play a significant role.

Cortical Excitability:

• Indicates the chronic nature of migraines.

• Migraine sufferers often have a more excitable brain, making certain events (e.g., migraine aura) easily triggered.

• Genetic factors contribute to increased excitability.

Significance for Management:

• Understanding the postdrome is crucial for effective migraine management.

• Comprehensive awareness of symptoms and involvement of key brain structures aids in developing targeted management strategies.